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Circadian control of glucose homeostasis: hormonal and autonomic mechanisms

Slides (presentatie) - Mar. 12, 2009

CIRCADIAN CONTROL OF GLUCOSE HOMEOSTASIS: Insights in mechanisms


Hypothalamus

The Human Biological Clock

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Vasopressin-immunoreactivity in a rat hypothalamic slice

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Schwartz et al., Nature, 2000

So the circadian master clock resides in the hypothalamus, but since the discovery of the clock genes we know that there are……

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Bregma 1.8 mm

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The SCN-pineal circadian axis

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Paraventricular nucleus of the hypothalamus (PVN) neuro-endocrine output center of the hypothalamus

Autonomic PVN neurons

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The balance of life

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Plasma glucose is the resultant of glucose production and glucose uptake

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Autonomic innervation

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The Trans-synaptic Viral Tracing Technique

The Trans-synaptic Viral Tracing Technique

The Trans-synaptic Viral Tracing Technique

How does the SCN control glucose metabolism?

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Effect of SCN ablation on BIC-induced hyperglycemia

Effect of SCN ablation on BIC-induced hyperglycemia

SCN terminals on pre-autonomic neurons in the ventral and dorsal paraventricular nucleus

Sympathetic

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Time (min)

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Plasma glucose is the resultant of glucose production and glucose uptake

Yi et al., Submitted, 2008

Yi et al., Submitted, 2008

400 μm

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Circadian rhythm of orexin levels in the rat CSF

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Neuronal projections of the orexin system

Nature, 2007, 443, 261-263

Marx, Science, 2003

Marx, Science, 2003

Arc

Ghrelin

SCN

Estrogen

The autonomic nervous system is an important gateway for the hypothalamus (incl. the biological clock) to convey its message to the periphery

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Orexin stimulates sympathetic preganglionic (liver) neurons

SCN

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