Cardiovasculaire Geneeskunde.nl

2e prijs Rinke Stienstra

Slides (presentatie) - Oct. 13, 2011

Inflammasome-mediated caspase-1 activity Gatekeeper of inflammation in the adipose tissue

Obesity promotes the development of insulin resistance and type 2 diabetes

Obesity, the adipose tissue and type 2 diabetes

Adipose tissue as an endocrine organ secretion of a wide variety of ‘adipokines’

Adipose tissue inflammation

The pro-inflammatory cytokine IL-1β and Type 2 Diabetes Current knowledge

The NLRP3-inflammasome controls IL-1β release

Is caspase-1 present in adipose tissue and regulated during obesity ?

Caspase-1 activation in adipose tissue is accompanied by increased levels of IL-1β

High fat diet-induced obesity in caspase-1-/- animals

Adipose tissue inflammation in HFD-fed wild-type and caspase-1-/- animals

Improvement in systemic insulin sensitivity in the absence of caspase-1 ?

Inhibition of caspase-1 in obese and insulin resistant animals ?

Insulin sensitivity is robustly improved in Ob/Ob animals after 2 weeks of caspase-1 inhibition

The inflammasome and caspase-1 in human adipose tissue

IL-1β secretion by human VAT vs. SAT ?

Inhibition of caspase-1 specifically inhibits IL-1β production by VAT

Summary

Future perspective Identification of potential triggers of inflammasome activation

Conclusion

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