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Etiology of embolism
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Arterial vascular disease
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Leading Causes of Mortality and Burden of Disease Worldwide
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Global projections for selected causes, 2004 to 2030
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Red alert for women’s heart
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Arterial and Venous Thrombosis
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Atherosclerotic Plaque Progression
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Coagulation and the arterial vessel wall
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Thrombus age after thrombosuction
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Histological spectrum of thrombus and atherosclerotic plaque tissue
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IF STAININGS – CO-LOCALIZATION OF TF, FVII & FX
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EARLY ATHEROSCLEROSIS EXHIBITS AN ENHANCED PRO-COAGULANT STATE
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SIGNIFICANTLY HIGHER ETP & TAT IN EARLY ATHEROSCLEROTIC LESIONS
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Is the level of thrombin generated in blood clinically relevant?
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Thrombin being proatherogenic?
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PHENOTYPIC MODULATION OF THE ARTERIAL VESSEL WALL
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Thrombin and atherosclerosis: causality?
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EXTENSIVE ATHEROSCLEROSIS IN TM Pro/Pro / ApoE-/- CAROTID ARTERIES
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INCREASED ACCUMULATION OF MФ AND LESS α-ACTIN AND COLLAGEN I/III IN TM Pro/Pro / ApoE-/-
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INTRAPLAQUE HEMORRHAGE & PLAQUE RUPTURE IN TM Pro/Pro / ApoE-/- MICE
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INTRAPLAQUE HEMORRHAGE & PLAQUE RUPTURE IN MICE
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ENHANCED NEOANGIOGENESIS IN TM Pro/Pro / ApoE-/- MICE
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Clinical manifestations of atheroembolism
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Treatment?
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In the coagulation arena: new avenues?
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Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization
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Secondary prevention
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DABIGATRAN/APC PROTECTS AGAINST SEVERE ATHEROSCLEROSIS PROGRESSION IN TM Pro/Pro / ApoE-/-
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ResultsI/R injury : Evans Blue/TTC staining
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Antithrombotic therapy
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