Cardiovasculaire Geneeskunde.nl

Etiology of embolism

Slides (presentatie) - Dec. 12, 2011

Etiology of embolism


Deze presentatie is gehouden door:
Prof. dr. Hugo ten Cate
Maastricht Universitair Medisch Centrum

tijdens het symposium ter gelegenheid van de oraties van prof. dr. E.S.G. Stroes en prof. dr. S. Middeldorp op 16 september 2011
 


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Etiology of embolism

Arterial vascular disease

Leading Causes of Mortality and Burden of Disease Worldwide

Global projections for selected causes, 2004 to 2030

Red alert for women’s heart

Arterial and Venous Thrombosis

Atherosclerotic Plaque Progression

Coagulation and the arterial vessel wall

Thrombus age after thrombosuction

Histological spectrum of thrombus and atherosclerotic plaque tissue

IF STAININGS – CO-LOCALIZATION OF TF, FVII & FX

EARLY ATHEROSCLEROSIS EXHIBITS AN ENHANCED PRO-COAGULANT STATE

SIGNIFICANTLY HIGHER ETP & TAT IN EARLY ATHEROSCLEROTIC LESIONS

Is the level of thrombin generated in blood clinically relevant?

Thrombin being proatherogenic?

PHENOTYPIC MODULATION OF THE ARTERIAL VESSEL WALL

Thrombin and atherosclerosis: causality?

EXTENSIVE ATHEROSCLEROSIS IN TM Pro/Pro / ApoE-/- CAROTID ARTERIES

INCREASED ACCUMULATION OF MФ AND LESS α-ACTIN AND COLLAGEN I/III IN TM Pro/Pro / ApoE-/-

INTRAPLAQUE HEMORRHAGE & PLAQUE RUPTURE IN TM Pro/Pro / ApoE-/- MICE

INTRAPLAQUE HEMORRHAGE & PLAQUE RUPTURE IN MICE

ENHANCED NEOANGIOGENESIS IN TM Pro/Pro / ApoE-/- MICE

Clinical manifestations of atheroembolism


Treatment?

In the coagulation arena: new avenues?

Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization


Secondary prevention

DABIGATRAN/APC PROTECTS AGAINST SEVERE ATHEROSCLEROSIS PROGRESSION IN TM Pro/Pro / ApoE-/-

ResultsI/R injury : Evans Blue/TTC staining

Antithrombotic therapy

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