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Reverse cholesterol transport: Novel insights

Slides (presentatie) - Dec. 12, 2011

Reverse cholesterol transport: Novel insights
 

Deze presentatie is gehouden door:
Prof. dr. Bert Groen
Universitair Medisch Centrum Groningen

tijdens het symposium ter gelegenheid van de oraties van prof. dr. E.S.G. Stroes en prof. dr. S. Middeldorp op 16 september 2011


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Reverse cholesterol transport: Novel insights Prof. dr. Bert Groen Universitair Medisch Centrum Groningen

Definition of reverse cholesterol transport (RCT)

Simplified scheme of cholesterol homeostasis

Classic scheme of reverse cholesterol transport

Disruption of Acba1 should have a drastic effect on fecal neutral sterol excretion

Disruption of Abca1 in mice has no effect on neutral sterol excretion in feces

Determination of tissue cholesterol efflux using 13C-Cholesterol infusion (Kinemed method)

Classic scheme of reverse cholesterol transport

About 40% of tissue cholesterol efflux in humans is HDL dependent

Summary I

Intestine perfusion

Intestinal perfusion to measure direct cholesterol secretion

Trans Intestinal Cholesterol Excretion (TICE)

Transintestinal cholesterol secretion (TICE)= transport directly from blood to intestinal lumen

In vivo determination of TICE in mice is straightforward.

Summary II

In vivo determination of TICE in humans is complicated because biliary cholesterol output has to be quantified

Estimation of biliary cholesterol output

Study protocol

Simplified model of cholesterol fluxes

Summary III

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