Cardiovasculaire Geneeskunde.nl

Immunomodulation & island-cell transplantation: Diabetes cured in 7 years?

Slides (presentatie) - Mar. 28, 2012

Immunomodulation & island-cell transplantation: Diabetes cured in 7 years?


Deze presentatie is gehouden door:
Dr. Eelco de Koning, internist, Leids Universitair Medisch Centrum
tijdens de Cardio Vasculaire Conferentie op 16 maart 2012


Bekijk of download de presentatie


 


Immunomodulation & island-cell transplantation: Diabetes cured in 7 years?

Diabetes mellitus is a beta-cell disease


Immunomodulation - diabetes cured in 7 years?

Prevention

Prevention

Rationale for late intervention: preservation of residual beta-cell function

Sustainded beta-cell function is associated with a reduced rate of new-onset albuminuria or worsening of retinopathy

Potential late interventions for preservation of beta-cell mass






Targeting islet inflammation in de novo type 1 diabetes for β-cell preservation

Prevention

Islet transplantation - diabetes cured in 7 years?

Curing diabetes! Pancreas transplantation

Regression of coronary atherosclerosis after pancreas transplantation

Benefit of SPK over LDK transplantation in recipients with type 1 diabetes

Islet transplantation – since 2007 in the Netherlands (LUMC) (5-10/year)

Islet isolation procedure


Transplantation outcome

Clinical benefit: chronic diabetic complications

Clinical benefit in islet-after kidney: improved kidney graft survival

Current options for beta-cell therapy in the LUMC

Shortage of organ donors NL 256 (2011)

Evidence for islet neogenesis from the duct epithelium in human adults

Isolation of human duct cells after islet isolation

Intact ducti develop “organoids” in matrigel

In vivo differentiation: organoid transplantation under the kidney capsule

Organoids under the kidney capsule differentiate to insulin producing cells

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