Cardiovasculaire Geneeskunde.nl

New techniques to screen (high output) microbiota

Slides (presentatie) - Mar. 28, 2012

New techniques to screen (high output) microbiota


Deze presentatie is gehouden door:
Dr. Fredrik Bäckhed, University of Gothenburg, Sweden
tijdens de Cardio Vasculaire Conferentie op 15 maart 2012

Bekijk of download de presentatie



New techniques to screen (high output) microbiota

The normal gut microbiota


Animalcules (microbiota in 1683)

Metagenomics of the Gut with the objective to identify prognostic biomarkers for disease

Spatial distributions of microbial phyla in healthy humans

Does obesity affect gut microbial ecology?

Obese mice have fewer Bacteroidetes, more Firmicutes

Reduced diversity of the gut microbiota in obese individuals

Germ-free mice are leaner than conventionally raised mice

Model


Gut microbiota modulates the serum metabolome

The gut microbiota alters adipose lipid composition

Bile acid metabolism

Atherosclerosis �� an inflammatory lipid disorder

Distinct microbial signatures in the gut, mouth and atherosclerotic plaque

Key hypothesis

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