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Molecular regulation of macrophages: implications for atherosclerosis
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Atherosclerosis is an inflammatory disease
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Anti-inflammatory clinical trials
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Atherosclerosis is an inflammatory disease with a critical role for monocyte recruitment
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Macrophages in human plaque development
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M1-M2 macrophage paradigm
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Macrophages in human plaque development
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M1-M2 macrophage paradigm
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Type I interferons
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Type I interferons: in vitro effects on macrophages
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Type I interferons: in vitro effects on macrophages
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Type I interferons: in vitro effects on macrophages
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Static macrophage adhesion
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In vivo leukocyte arrest
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IFNβ treatment of ldlr-/- mice
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Human plaque transcriptome: comparing stable vs unstable lesions
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What happens to the inflammatory phenotype when a macrophage becomes a foam cell?
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Foam cell formation by oxLDL switches macrophages to a pro-inflammatory state
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M1-M2 macrophage paradigm
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