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Molecular regulation of macrophages: implications for

Slides (presentatie) - Mar. 29, 2012

Molecular regulation of macrophages: implications for atherosclerosis


Deze presentatie is gehouden door:
Dr. Menno de Winther, Academisch Medisch Centrum, Amsterdam
tijdens de Cardio Vasculaire Conferentie op 16 maart 2012


Bekijk of download de presentatie


Molecular regulation of macrophages: implications for atherosclerosis

Atherosclerosis is an inflammatory disease

Anti-inflammatory clinical trials

Atherosclerosis is an inflammatory disease with a critical role for monocyte recruitment

Macrophages in human plaque development

M1-M2 macrophage paradigm


Macrophages in human plaque development

M1-M2 macrophage paradigm

Type I interferons

Type I interferons: in vitro effects on macrophages

Type I interferons: in vitro effects on macrophages

Type I interferons: in vitro effects on macrophages

Static macrophage adhesion

In vivo leukocyte arrest

IFNβ treatment of ldlr-/- mice

Human plaque transcriptome: comparing stable vs unstable lesions


What happens to the inflammatory phenotype when a macrophage becomes a foam cell?

Foam cell formation by oxLDL switches macrophages to a pro-inflammatory state

M1-M2 macrophage paradigm

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