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Cardiovascular Exchange Summit 2011
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NORTHWICK PARK HEART STUDY II
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RISK SCORE METHODS - PROCAM/Framingham
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CRFs Predict Poorly in UK Middle-Aged Men
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CRP : Origin, Clearance and Function
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Adding CRP to algorithm Risk Score in NPHSII
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Will genotype predict risk over-and-above trait
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Genome Wide Scans – case control approach
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Major New “Gene” for MI/CHD Identified on Chromosome 9
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Is Chr9 SNP CHD risk effect robust?
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ROC to test predictive power
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Chr9 SNP and Risk Prediction in NPHSII men
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SEVEN GWAS SNPs FOR CHD RISK IDENTIFIED
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Current CHD GWAS loci
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Combining Modest-Risk Genotypes – Gene Score
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Distribution of Risk alleles in NPHSII men
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Where is the rest of the Genetic contribution ?
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ELSI - Risk Perception and Behaviour Change
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CARE PATHWAY FOR CARDIOVASCULAR RISK CLINIC
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